Observations on the B cell repertoire in young and elderly people

Since I have not written for a while I decided to choose for my comeback something that could be summarized in couple of shorts paragraph, something that I am not very familiar with, so I am not grounded in endless divagations yet something that is of enough interest to whet my appetite for more posts to come soon. I selected an article that compares the overall B cell repertoires between humans that are respectively young or elderly as well as brings an additional variable to the age parameter, that is the seropositivity for either CMV or EBV.

The link: http://www.jimmunol.org/content/192/2/603

This is a study in which authors analyze the rearanged heavy chain gene sequences from PMBC cells isolated from peripheral blood of study participants that are assigned to three different age group. Additionally all collected samples were assessed for the presence of anti-CMV or EBV antibodies. The conclusions could be put in a nutshell in few sentences. There seems to be no difference in V, D and J usage between young and elderly age groups. However, the older age appears to correlate with lengthening of the CDR3 region. People advanced in years also harbor more highly mutated IgM and IgG Ig genes and some of them display a trend towards the accumulation of expanded and persistent B cell clones. Last but not least, either the chronic infection with CMV or EBV appears to imprint its own discreet mark on the overall B cell repertoire.

Krishna M. Roskin, Tho D. Pham, Jonathan Laserson, Chen Wang, Yi Liu, Lan T. Xu, Katherine J. L. Jackson, Eleanor L. Marshall, Katie Seo, Ji-Yeun Lee, David Furman, Daphne Koller, Cornelia L. Dekker, Mark M. Davis, Andrew Z. Fire and Scott D. Boyd (2014). Effects of Aging, Cytomegalovirus Infection, and EBV Infection on Human B Cell Repertoires. Journal of Immunology DOI: 10.4049/jimmunol.1301384

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